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March 16 US: Chemical Listed Effective March 16, 2012 as Known to the State of California to Cause Reproductive Toxicity: Methanol

March 16th, 2012

From OEHHA:

Effective March 16, 2012, the Office of Environmental Health Hazard Assessment (OEHHA) is adding methanol (CAS No. 67-56-1) to the list of chemicals known to the State to cause reproductive toxicity for purposes of Proposition 65.1

The listing of methanol is based on formal identification by the National Toxicology Program (NTP), an authoritative body,2 in a report by the NTP Center for the Evaluation of Risks to Human Reproduction, that methanol causes reproductive toxicity (developmental endpoint).  The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306.

The documentation supporting OEHHA’s determination that the criteria for administrative listing have been satisfied for methanol is included in the Notice of Intent to List [Can you create a hyperlink to this Notice of Intent to List] published in the January 2, 2009 issue of the California Regulatory Notice Register (Register 2009, No. 1-Z).

A complete, updated chemical list is published in this issue of the California Regulatory Notice Register and is available on the OEHHA website at www.oehha.ca.gov.  In summary, methanol is being listed under Proposition 65 as known to the State to cause reproductive toxicity, as follows:

Chemical CAS No. Toxicological Endpoints Listing Mechanism3
Methanol 67-56-1 developmental AB (NTP)

1The Safe Drinking Water and Toxic Enforcement Act of 1986, Health and Safety Code section 25249.5 et seq.

2 See Health and Safety Code, section 25249.8(b) and Title 27, Cal. Code of Regs., section 25306.

3 Listing mechanism:  AB – “authoritative bodies” mechanism (Title 27, Cal. Code of Regs. Section 25306).

Because of the significant public interest in methanol, an Interpretive Guideline No. 2012-001 is being published concurrently with this rulemaking notice. Follow this link to download a copy of the Interpretive Guideline.

We will keep you updated with any ongoing Prop 65 developments.

Jan. 25 US: OEHHA is Requesting Information on the Reproductive Toxicity of Deltamethrin and Xylene

January 25th, 2012

From: OEHHA

OEHHA has selected the chemicals below for the DARTIC’s review for possible listing under Proposition 65.  OEHHA is initiating the development of hazard identification materials on these chemicals.

Chemicals Selected for Preparation of Reproductive Toxicity Hazard Identification Materials
Chemical CAS No.
Deltamethrin 52918-63-5
Xylene 1330-20-7

By this notice, OEHHA is giving the public an opportunity to provide information relevant to the assessment of the evidence of developmental and male and female reproductive toxicity for deltamethrin and xylene.  Interested parties or members of the public wishing to provide such information should send it to the address given below.

The publication of this notice marks the start of a 60-day data call-in period.  This period will end on Tuesday, March 20, 2012.  The information received during this data call-in period will be reviewed and considered by OEHHA as it prepares the reproductive toxicity hazard identification materials on these chemicals.

For more information, please click on the above link.

Jan. 23 US: Four New Chemicals Intended to be Listed on Proposition 65

January 23rd, 2012

From: OEHHA

Health Canada’s sampling and evaluation program has revealed that the recalled piece of jewellery contains lead in excess of the allowable limit.

Chemical CAS No. Endpoint References
Benzophenone 119-61-9 Cancer IARC (2011);
Grosse et al. (2011)
Coconut oil diethanolamine condensate (cocamide diethanolamine) 68603-42-9 Cancer IARC (2011);
Grosse et al. (2011)
Diethanolamine 111-42-2 Cancer IARC (2011);
Grosse et al. (2011)
2-Methylimidazole 693-98-1 Cancer IARC (2011);
Grosse et al. (2011)

Benzophenone, coconut oil diethanolamine condensate (cocamide diethanolamine), diethanolamine, and 2-methylimidazole each meet the requirements for listing as known to the state to cause cancer for purposes of Proposition 65.

OEHHA is providing this opportunity to comment as to whether the chemicals identified above meet the requirements for listing as causing cancer specified in Health and Safety Code section 25249.8(a). OEHHA must receive comments by 5:00 p.m. on Tuesday, February 21, 2012.

Click on the links for more information.

Jan. 9 US: Notice of Intent to List Methyl Isopropyl Ketone

January 9th, 2012

From: OEHHA

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemical identified in the table below as known to the State to cause reproductive toxicity under the Safe Drinking Water and Toxic Enforcement Act of 1986.

Chemical CAS No. Reproductive
Toxicity
Endpoint
Reference
Methyl isopropyl ketone 563-80-4 Developmental toxicity ACGIH (2011)

OEHHA is providing an opportunity to comment as to whether the chemical identified above meets the requirements for listing as causing reproductive toxicity, specified in Health and Safety Code section 25249.8(a).  Because this is a ministerial listing, comments should be limited to the question whether the ACGIH has assigned a TLV based in whole or in part on an endpoint of reproductive toxicity.

All comments must be received by 5:00 p.m. on Monday, January 30, 2012.

Click on the links for more information.

Dec. 2 US: Notice of Intent to List Intent to List Kresoxim-Methyl and Tetraconazole

December 2nd, 2011

From OEHHA:

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemicals kresoxim-methyl and tetraconazole as known to the State to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being proposed under the authoritative bodies listing mechanism.

Chemical
(CAS No.)
Endpoint Reference Occurrence
Kresoxim-methyl
(143390-89-0)
Cancer U.S. EPA (1999) Fungicide used on apples, cherries, grapes, pears, pome fruits and pecans
Tetraconazole
(112281-77-3)
Cancer U.S. EPA (2000) Triazole fungicide used to control leafspot and powdery mildew on sugar beets

OEHHA requested information relevant to the possible listing of kresoxim-methyl and tetraconazole in a notice published in the California Regulatory Notice Register on October 22, 2010 (Register 2010, Vol. No. 43-Z). OEHHA received public comments on both chemicals.

Background on listing via the authoritative bodies mechanism: A chemical must be listed under the Proposition 65 regulations when two conditions are met:

  1. An authoritative body formally identifies the chemical as causing cancer (Section 25306(d) ).
  2. The evidence considered by the authoritative body meets the sufficiency criteria contained in the regulations (Section 25306(e)).

However, the chemical is not listed if scientifically valid data which were not considered by the authoritative body clearly establish that the sufficiency of evidence criteria were not met (Section 25306(f)).

The U.S. Environmental Protection Agency (U.S. EPA) is one of several institutions designated as authoritative for the identification of chemicals as causing cancer (Section 25306(m)).

OEHHA is the lead agency for Proposition 65 implementation. After an authoritative body has made a determination about a chemical, OEHHA evaluates whether listing under Proposition 65 is required using the criteria contained in the regulations.

OEHHA’s determination: Kresoxim-methyl and tetraconazole each meet the criteria for listing as known to the State to cause cancer under Proposition 65, based on findings of the U.S. EPA (U.S. EPA, 1999; U.S. EPA, 2000).

The full article can be found here.

We will keep you informed of any future updates.

Nov. 22 US: Announcement of Chemicals Selected by OEHHA for Consideration for Listing by the Carcinogen Identification Committee

November 22nd, 2011

From OEHHA:

OEHHA has selected the chemicals below for the CIC’s review for possible listing under Proposition 65.  OEHHA is initiating the development of hazard identification materials on these chemicals.

Chemical Name                                                                  CAS#

C.I. Disperse Yellow                                             32832-40-8

Dibenzanthracenes and dibenz[a,c]anthracene             215-58-7

Hazard identification materials for the chemicals in the table above will be presented at future meetings of the CIC for Committee review for possible listing under Proposition 65.

By this notice, OEHHA is giving the public an opportunity to provide information relevant to the assessment of the evidence of carcinogenicity for the chemicals shown above.  Relevant information includes but is not limited to:

  • cancer bioassays
  • cancer epidemiological studies
  • genotoxicity testing
  • other pertinent data on:
    • pharmacokinetics,
    • biomarkers
    • effects on biochemical and physiological processes in humans.

Interested parties or members of the public wishing to provide such information should send it to the address given below.

The publication of this notice marks the start of a 60-day data call-in period, ending on Tuesday, January 10, 2012.  The information received during this period will be reviewed and considered by OEHHA as it prepares the cancer hazard identification materials on these chemicals.

We encourage you to submit relevant information on these chemicals in electronic form, rather than in paper form.  Submissions transmitted by e-mail should be addressed to P65Public.Comments@oehha.ca.gov.  Please include the chemical name in the subject line.  Submissions in paper form may be mailed, faxed, or delivered in person to the addresses below:

Mailing Address: Ms. Cynthia Oshita
Office of Environmental Health Hazard Assessment
P.O. Box 4010, MS-19B
Sacramento, California 95812-4010
Fax: (916) 323-8803
Street Address: 1001 I Street
Sacramento, California 95814

For more information click the links above.

Nov. 14 US: Summary of Carcinogen Identification Committee Meeting Held on October 12, 2011

November 11th, 2011

From: OEHHA

A meeting of the Proposition 651 Carcinogen Identification Committee (CIC) was held on October 12, 2011, at the California Environmental Protection Agency Headquarters Building in Sacramento, California.  The Committee considered the listing of Tris(1,3-dichloro-2-propyl) phosphate and fluoride and its salts as known to the state cause cancer.  The Committee also provided OEHHA with its advice concerning the relative priority of 39 chemicals for possible hazard identification material preparation.  In addition, the Committee discussed procedures for public comment presentations, committee discussions and committee voting.

Go to the link below for access to the summary of this meeting, including slide presentations.

http://oehha.ca.gov/prop65/public_meetings/cic101211synop.html

Nov. 3 US: New chemical added to Proposition 65 List

November 3rd, 2011

From: OEHHA

Effective October 28, 2011, the Office of Environmental Health Hazard Assessment (OEHHA) is adding tris(1,3-dichloro-2-propyl) phosphate (TDCPP) (CAS No. 13674-87-8) to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65).

Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) was considered by the Carcinogen Identification Committee (CIC) in its official capacity as the “state’s qualified experts” at a public meeting held on October 12, 2011.  The CIC determined that tris(1,3-dichloro-2-propyl) phosphate (TDCPP) was clearly shown, through scientifically valid testing according to generally accepted principles, to cause cancer.

A revised Propsition 65 list in available on the OEHHA website.

Sept. 12 US: Titanium dioxide now listed as known to the State Of California to cause Cancer

September 12th, 2011

From OEHHA:

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding titanium dioxide (airborne, unbound particles of respirable size) to the list of chemicals known to the State of California to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ).  The listing does not cover titanium dioxide when it remains bound within a product matrix.  The listing of titanium dioxide (airborne, unbound particles of respirable size) is effective September 2, 2011.

For more information or the current Proposition 65 list see the above link.

Aug. 11 US: Meeting Synopsis and Slide Presentations From Committee Meeting Held On July 12 and 13 Now Available

August 11th, 2011

From: OEHHA

The California Environmental Protection Agency’s (Cal/EPA), Office of Environmental Health Hazard Assessment (OEHHA) convened a meeting of the Proposition 65 Developmental and Reproductive Toxicant Identification Committee (DARTIC) on July 12 and 13, 2011. The meeting was held at the Cal/EPA Headquarters Building in Sacramento, California.

Following a staff presentation, comments from the public and committee discussion, the DARTIC determined that sulfur dioxide has been clearly shown to cause developmental toxicity based on findings of low birth weight in scientific studies.  The chemical was added to the Proposition 65 chemical list as known to cause reproductive toxicity (developmental toxicity endpoint) effective July 29, 2011.  The DARTIC did not find that sulfur dioxide has been clearly shown to cause female or male reproductive toxicity.

Click on the link above for more information on this committee meeting, or to view these documents.