From the EPA:

EPA is proposing a test rule under section 4(a)(1)(B) of the Toxic Substances Control Act (TSCA) to require manufacturers, importers, and processors of certain high production volume (HPV) chemical substances to conduct testing to obtain screening level data for health and environmental effects and chemical fate. EPA has preliminarily determined that: Each of the 19 chemical substances included in this proposed rule is produced in substantial quantities and that there is or may be substantial human exposure to each of them; there are insufficient data to reasonably determine or predict the effects on health or the environment of the manufacture, distribution in commerce, processing, use, or disposal of the chemicals, or of any combination of these activities; and the testing program proposed here is necessary to develop such data. Data developed under this proposed rule will provide critical information about the environmental fate and potential hazards associated with these chemicals which, when combined with information about exposure and uses, will allow the Agency and others to evaluate potential health and environmental risks and to take appropriate follow-up action. Persons who export or intend to export any chemical substance included in the final rule would be subject to the export notification requirements in TSCA section 12(b)(1) and at 40 CFR part 707, subpart D. EPA has also taken steps, as described in this document, to consider animal welfare and to provide instructions on ways to reduce or in some cases eliminate animal testing, while at the same time ensuring that the public health is protected.

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The CAS Numbers of the 19 chemical substances are as follows:

  • 75-07-0 : Acetaldehyde
  • 78-11-5 : 1,3-Propanediol, 2,2- bis[(nitrooxy)methyl]- , dinitrate (ester)
  • 84-65-1 : 9,10-Anthracenedione
  • 89-32-7 : 1H,3H-Benzo[1,2-c:4,5- c’]difuran-1,3,5,7- tetrone
  • 110-44-1 : 2,4-Hexadienoic acid, (E,E)-
  • 118-82-1 : Phenol, 4,4′- methylenebis[2,6- bis(1,1-dimethylethyl)-
  • 119-61-9 : Methanone, diphenyl-
  • 144-62-7 : Ethanedioic acid
  • 149-44-0 : Methanesulfinic acid, hydroxy-, monosodium salt
  • 2524-04-1 : Phosphorochloridothioic acid, O,O-diethyl ester
  • 4719-04-4 : 1,3,5-Triazine- 1,3,5(2H,4H,6H)- triethanol
  • 6381-77-7 : D-erythro-Hex-2-enonic acid, [gamma]-lactone, monosodium salt
  • 31138-65-5 : D-gluco-Heptonic acid, monosodium salt, (2.xi.)-
  • 66241-11-0 : C.I. Leuco Sulphur Black 1
  • 68187-76-8 : Castor oil, sulfated, sodium salt
  • 68187-84-8 : Castor oil, oxidized
  • 68479-98-1 : Benzenediamine, ar,ar- diethyl-ar-methyl-
  • 68527-02-6 : Alkenes, C12-24, chloro
  • 68647-60-9 : Hydrocarbons, C > 4